Endocrine Abstracts

GH receptor stimulation changes intracellular protein phosphorylation and activates the JAK-STAT signalling pathway. The JAK2 - STAT5 components of this pathway seem critical for growth. Factors of essence for cellular effects of GH include the duration of GH receptor stimulation and in different species there are sex differences in GH secretion where males have an episodic and females have a more continuous mode of GH secretion. At the cellular level, these two types of GH se...